Ten years after a catastrophic event a group of top-notch soldiers gathered from every branch of the now weakened United States military have formed an elite unit known as Ghosts. These brave soldiers must battle a new, unseen enemy that threatens the country that they serve.

Call of Duty: Ghosts takes place following a catastrophic event that changed the global balance of powers in the world. As a result, the United States is no longer recognized as a superpower. Ten years after the event, an unseen enemy emerges as a threat, but the remnants of US special operation forces from every branch came together to create an elite group of soldiers known as the "Ghosts", who are determined to eradicate all threats to protect the weak and the remains of America.