| Saber Interactive |
| Saffire |
| Sandblast Games |
| Sandlot |
| Sanzaru Games |
| Saturn+ |
| Savage Entertainment |
| SCE Japan Studio |
| SCE San Diego Studio |
| SCE Studios Santa Monica |
| SCEA |
| SCEE |
| SCEE Cambridge Studio |
| SCEE London Studio |
| SCEE Studio Liverpool |
| SCEI |
| SCEJ |
| Scholastic Interactive |
| SCi Entertainment Group |
| Screenlife Games |
| SCS Software |
| Seamless Entertainment |
| Seaward.ru |
| SeaWolf |
| Secret Level |
| Secret Stash Games |
| Sega |
| Sega-AM2 |
| SEK Ost |
| Sensory Sweep |
| Seta Corporation |
| Seven Lights |
| Seven Studios |
| Seven45 Studios |
| SevenOne |
| Shaba Games |
| Shadow Planet Productions |
| Shin'en |
| Shiny Entertainment |
| Shockwave Productions |
| Shrapnel Games |
| Sidhe Interactive |
| Sierra |
| Sierra Northwest |
| Sierra Studios |
| Sigil Games |
| Signal Studios |
| Silent Dreams |
| Silicon Dreams |
| Silicon Garage Arts |
| Silicon Knights |
| Silicon Studio |
| Silver Creek Entertainment |
| Silver Wish Games |
| SilverBirch Studio |
| Silverlode Interactive |
| SimBin |
| Similis |
| Simon and Schuster Interactive |
| Sir-Tech Canada |
